N150S (p.Asn150Ser) variant of TOP2A (DNA topoisomerase 2-alpha)
N150S (p.Asn150Ser) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
N150S (p.Asn150Ser) variant details
- p.Asn150Ser
- TOPMed rs1240257662
- gnomAD rs1240257662
- Missense
- Variant Prioritization Score for Impact Estimate 0.558
- REVEL 0.50
- CADD 25.40
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available