N10S (p.Asn10Ser) variant of TOP2A (DNA topoisomerase 2-alpha)
N10S (p.Asn10Ser) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
N10S (p.Asn10Ser) variant details
- p.Asn10Ser
- gnomAD rs1289313411
- Missense
- Variant Prioritization Score for Impact Estimate 0.147
- REVEL 0.02
- CADD 20.10
- PolyPhen-2 0.00
- SIFT 0.25
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available