M195V (p.Met195Val) variant of TOP2A (DNA topoisomerase 2-alpha)
M195V (p.Met195Val) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
M195V (p.Met195Val) variant details
- p.Met195Val
- Ensembl rs1598619477
- Missense
- Variant Prioritization Score for Impact Estimate 0.24
- REVEL 0.06
- CADD 18.60
- PolyPhen-2 0.00
- SIFT 0.55
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available