L89I (p.Leu89Ile) variant of TOP2A (DNA topoisomerase 2-alpha)
L89I (p.Leu89Ile) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
L89I (p.Leu89Ile) variant details
- p.Leu89Ile
- NCI-TCGA Cosmic COSV7073
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.349
- REVEL 0.24
- CADD 24.50
- PolyPhen-2 0.62
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available