K26N (p.Lys26Asn) variant of TOP2A (DNA topoisomerase 2-alpha)
K26N (p.Lys26Asn) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
K26N (p.Lys26Asn) variant details
- p.Lys26Asn
- ExAC rs761604860
- gnomAD rs761604860
- Missense
- Variant Prioritization Score for Impact Estimate 0.314
- REVEL 0.14
- CADD 25.50
- PolyPhen-2 0.80
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available