K26E (p.Lys26Glu) variant of TOP2A (DNA topoisomerase 2-alpha)
K26E (p.Lys26Glu) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
K26E (p.Lys26Glu) variant details
- p.Lys26Glu
- gnomAD rs1424484074
- Missense
- Variant Prioritization Score for Impact Estimate 0.332
- REVEL 0.12
- CADD 24.60
- PolyPhen-2 0.32
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available