K176R (p.Lys176Arg) variant of TOP2A (DNA topoisomerase 2-alpha)
K176R (p.Lys176Arg) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
K176R (p.Lys176Arg) variant details
- p.Lys176Arg
- gnomAD rs1329284445
- Missense
- Variant Prioritization Score for Impact Estimate 0.166
- REVEL 0.05
- CADD 21.00
- PolyPhen-2 0.05
- SIFT 0.16
- Most common in the African/African-American population (allele frequency 3.1e-05)
- Structural context available