I172V (p.Ile172Val) variant of TOP2A (DNA topoisomerase 2-alpha)
I172V (p.Ile172Val) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
I172V (p.Ile172Val) variant details
- p.Ile172Val
- Ensembl rs2035346240
- Missense
- Variant Prioritization Score for Impact Estimate 0.362
- REVEL 0.18
- CADD 23.50
- PolyPhen-2 0.38
- SIFT 0.03
- Population evidence available
- Structural context available