I109V (p.Ile109Val) variant of TOP2A (DNA topoisomerase 2-alpha)
I109V (p.Ile109Val) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
I109V (p.Ile109Val) variant details
- p.Ile109Val
- gnomAD rs1414600000
- Missense
- Variant Prioritization Score for Impact Estimate 0.249
- REVEL 0.14
- CADD 22.20
- PolyPhen-2 0.08
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.2e-05)
- Structural context available