I105F (p.Ile105Phe) variant of TOP2A (DNA topoisomerase 2-alpha)
I105F (p.Ile105Phe) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
I105F (p.Ile105Phe) variant details
- p.Ile105Phe
- Ensembl rs2143694751
- Missense
- Variant Prioritization Score for Impact Estimate 0.671
- REVEL 0.66
- CADD 31.00
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the South Asian population (allele frequency 2.4e-05)
- Structural context available