G166E (p.Gly166Glu) variant of TOP2A (DNA topoisomerase 2-alpha)
G166E (p.Gly166Glu) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.89 / 1. The record also includes population frequency data and structural context.
G166E (p.Gly166Glu) variant details
- p.Gly166Glu
- gnomAD rs1203971586
- Missense
- Variant Prioritization Score for Impact Estimate 0.893
- REVEL 0.97
- CADD 26.40
- PolyPhen-2 1.00
- SIFT 0.00
- Population evidence available
- Structural context available