G143V (p.Gly143Val) variant of TOP2A (DNA topoisomerase 2-alpha)
G143V (p.Gly143Val) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
G143V (p.Gly143Val) variant details
- p.Gly143Val
- Ensembl rs2143687832
- Missense
- Variant Prioritization Score for Impact Estimate 0.747
- REVEL 0.72
- CADD 26.30
- PolyPhen-2 1.00
- SIFT 0.00
- Population evidence available
- Structural context available