F77Y (p.Phe77Tyr) variant of TOP2A (DNA topoisomerase 2-alpha)
F77Y (p.Phe77Tyr) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
F77Y (p.Phe77Tyr) variant details
- p.Phe77Tyr
- gnomAD rs1203204555
- Missense
- Variant Prioritization Score for Impact Estimate 0.234
- REVEL 0.11
- CADD 17.40
- PolyPhen-2 0.01
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available