F177L (p.Phe177Leu) variant of TOP2A (DNA topoisomerase 2-alpha)
F177L (p.Phe177Leu) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
F177L (p.Phe177Leu) variant details
- p.Phe177Leu
- Ensembl rs2143686850
- Missense
- Variant Prioritization Score for Impact Estimate 0.466
- REVEL 0.44
- CADD 24.80
- PolyPhen-2 0.98
- SIFT 0.00
- Population evidence available
- Structural context available