D67N (p.Asp67Asn) variant of TOP2A (DNA topoisomerase 2-alpha)
D67N (p.Asp67Asn) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
D67N (p.Asp67Asn) variant details
- p.Asp67Asn
- NCI-TCGA Cosmic COSV1013
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.377
- REVEL 0.12
- CADD 23.60
- PolyPhen-2 0.00
- SIFT 0.16
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available