D65N (p.Asp65Asn) variant of TOP2A (DNA topoisomerase 2-alpha)
D65N (p.Asp65Asn) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
D65N (p.Asp65Asn) variant details
- p.Asp65Asn
- TOPMed rs2035392401
- Missense
- Variant Prioritization Score for Impact Estimate 0.409
- REVEL 0.16
- CADD 25.00
- PolyPhen-2 0.07
- SIFT 0.03
- Most common in the Latino/Admixed American population (allele frequency 7e-05)
- Structural context available