A93T (p.Ala93Thr) variant of TOP2A (DNA topoisomerase 2-alpha)
A93T (p.Ala93Thr) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
A93T (p.Ala93Thr) variant details
- p.Ala93Thr
- TOPMed rs1018933690
- gnomAD rs1018933690
- Missense
- Variant Prioritization Score for Impact Estimate 0.578
- REVEL 0.48
- CADD 29.10
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 9.7e-05)
- Structural context available