A92V (p.Ala92Val) variant of TOP2A (DNA topoisomerase 2-alpha)
A92V (p.Ala92Val) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
A92V (p.Ala92Val) variant details
- p.Ala92Val
- Ensembl rs2143694901
- Missense
- Variant Prioritization Score for Impact Estimate 0.752
- REVEL 0.69
- CADD 32.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available