A92S (p.Ala92Ser) variant of TOP2A (DNA topoisomerase 2-alpha)
A92S (p.Ala92Ser) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
A92S (p.Ala92Ser) variant details
- p.Ala92Ser
- gnomAD rs1203191432
- Missense
- Variant Prioritization Score for Impact Estimate 0.635
- REVEL 0.52
- CADD 26.80
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available