S74* (p.Ser74Ter) variant of TOP1 (DNA topoisomerase 1)
S74* (p.Ser74Ter) in TOP1 (DNA topoisomerase 1) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.85 / 1. The record also includes population frequency data and structural context.
S74* (p.Ser74Ter) variant details
- p.Ser74Ter
- NCI-TCGA Cosmic COSV6369
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.854
- CADD 36.00
- UniProt: Variant assessed as somatic; high impact.
- Population evidence available
- Structural context available