S10Y (p.Ser10Tyr) variant of TOP1 (DNA topoisomerase 1)
S10Y (p.Ser10Tyr) in TOP1 (DNA topoisomerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
S10Y (p.Ser10Tyr) variant details
- p.Ser10Tyr
- gnomAD 20-41029096-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.296
- REVEL 0.11
- MetaLR 0.10
- MetaSVM -1.01
- CADD 24.00
- PolyPhen-2 0.96
- SIFT 0.09
- Population evidence available
- Structural context available
- Literature evidence available