S10F (p.Ser10Phe) variant of TOP1 (DNA topoisomerase 1)
S10F (p.Ser10Phe) in TOP1 (DNA topoisomerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
S10F (p.Ser10Phe) variant details
- p.Ser10Phe
- gnomAD 20-41029096-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.303
- REVEL 0.12
- MetaLR 0.10
- MetaSVM -1.01
- CADD 24.70
- PolyPhen-2 0.96
- SIFT 0.02
- Population evidence available
- Structural context available
- Literature evidence available