Q11H (p.Gln11His) variant of TOP1 (DNA topoisomerase 1)
Q11H (p.Gln11His) in TOP1 (DNA topoisomerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, published literature, and structural context.
Q11H (p.Gln11His) variant details
- p.Gln11His
- gnomAD 20-41029100-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.387
- REVEL 0.13
- MetaLR 0.10
- MetaSVM -1.07
- CADD 34.00
- PolyPhen-2 0.95
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available