K25R (p.Lys25Arg) variant of TOP1 (DNA topoisomerase 1)
K25R (p.Lys25Arg) in TOP1 (DNA topoisomerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
K25R (p.Lys25Arg) variant details
- p.Lys25Arg
- TOPMed rs1302095474
- gnomAD rs1302095474
- Missense
- Variant Prioritization Score for Impact Estimate 0.308
- REVEL 0.12
- MetaLR 0.10
- MetaSVM -1.09
- CADD 24.90
- SIFT 0.04
- Most common in the 1KG:CLM population (allele frequency 0.0053)
- Structural context available