H77N (p.His77Asn) variant of TOP1 (DNA topoisomerase 1)
H77N (p.His77Asn) in TOP1 (DNA topoisomerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
H77N (p.His77Asn) variant details
- p.His77Asn
- Ensembl rs2145935038
- Missense
- Variant Prioritization Score for Impact Estimate 0.316
- REVEL 0.06
- MetaLR 0.04
- MetaSVM -1.08
- CADD 20.80
- PolyPhen-2 0.38
- SIFT 0.05
- Population evidence available
- Structural context available