H22H (p.His22His) variant of TOP1 (DNA topoisomerase 1)
H22H (p.His22His) in TOP1 (DNA topoisomerase 1) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, published literature, and structural context.
H22H (p.His22His) variant details
- p.His22His
- rs2145926971
- gnomAD 20-41061401-T-C
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.529
- CADD 9.26
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)
- Structural context available
- Literature evidence available