G3W (p.Gly3Trp) variant of TOP1 (DNA topoisomerase 1)
G3W (p.Gly3Trp) in TOP1 (DNA topoisomerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, published literature, and structural context.
G3W (p.Gly3Trp) variant details
- p.Gly3Trp
- gnomAD 20-41029074-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.419
- REVEL 0.20
- MetaLR 0.11
- MetaSVM -0.99
- CADD 32.00
- PolyPhen-2 1.00
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available