G3R (p.Gly3Arg) variant of TOP1 (DNA topoisomerase 1)
G3R (p.Gly3Arg) in TOP1 (DNA topoisomerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, published literature, and structural context.
G3R (p.Gly3Arg) variant details
- p.Gly3Arg
- gnomAD 20-41029074-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.418
- REVEL 0.21
- MetaLR 0.11
- MetaSVM -1.00
- CADD 31.00
- PolyPhen-2 1.00
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available