D4D (p.Asp4Asp) variant of TOP1 (DNA topoisomerase 1)
D4D (p.Asp4Asp) in TOP1 (DNA topoisomerase 1) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data, published literature, and structural context.
D4D (p.Asp4Asp) variant details
- p.Asp4Asp
- gnomAD 20-41029079-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.562
- CADD 14.30
- Most common in the HGDP:FRENCH population (allele frequency 0.019)
- Structural context available
- Literature evidence available