D26N (p.Asp26Asn) variant of TOP1 (DNA topoisomerase 1)
D26N (p.Asp26Asn) in TOP1 (DNA topoisomerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
D26N (p.Asp26Asn) variant details
- p.Asp26Asn
- gnomAD rs1411426916
- Missense
- Variant Prioritization Score for Impact Estimate 0.34
- REVEL 0.10
- MetaLR 0.05
- MetaSVM -1.13
- CADD 24.00
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available