P94S (p.Pro94Ser) variant of TNXB (Tenascin-X)
P94S (p.Pro94Ser) in TNXB (Tenascin-X) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
P94S (p.Pro94Ser) variant details
- p.Pro94Ser
- rs767342071
- NCI-TCGA Cosmic COSV6448
- cosmic curated COSV64489
- ExAC rs767342071
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.355
- REVEL 0.29
- ESM-1b 0.00
- AlphaMissense 0.14
- CADD 23.60
- PolyPhen-2 1.00
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available