P81S (p.Pro81Ser) variant of TNXB (Tenascin-X)
P81S (p.Pro81Ser) in TNXB (Tenascin-X) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
P81S (p.Pro81Ser) variant details
- p.Pro81Ser
- rs746282620
- NCI-TCGA Cosmic COSV1009
- cosmic curated COSV10092
- ExAC rs746282620
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.187
- REVEL 0.08
- ESM-1b 0.37
- AlphaMissense 0.09
- CADD 15.40
- PolyPhen-2 0.16
- SIFT 0.13
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available