G86D (p.Gly86Asp) variant of TNXB (Tenascin-X)
G86D (p.Gly86Asp) in TNXB (Tenascin-X) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
G86D (p.Gly86Asp) variant details
- p.Gly86Asp
- NCI-TCGA Cosmic COSV6449
- cosmic curated COSV64490
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.596
- REVEL 0.41
- ESM-1b 1.00
- AlphaMissense 0.26
- CADD 25.70
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available