Q108E (p.Gln108Glu) variant of TNFRSF9 (Q07011)
Q108E (p.Gln108Glu) in TNFRSF9 (Q07011) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
Q108E (p.Gln108Glu) variant details
- p.Gln108Glu
- rs147680622
- ClinGen CA569283
- cosmic curated COSV66349
- ClinVar RCV002033855
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.241
- REVEL 0.21
- CADD 7.43
- PolyPhen-2 0.00
- SIFT 1.00
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 0.00032)
- Structural context available