G70S (p.Gly70Ser) variant of TNFRSF9 (Q07011)
G70S (p.Gly70Ser) in TNFRSF9 (Q07011) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
G70S (p.Gly70Ser) variant details
- p.Gly70Ser
- NCI-TCGA Cosmic COSV1010
- cosmic curated COSV10109
- NCI-TCGA Cosmic COSV6634
- TOPMed rs1399281402
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.64
- REVEL 0.48
- CADD 35.00
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available