G70C (p.Gly70Cys) variant of TNFRSF9 (Q07011)
G70C (p.Gly70Cys) in TNFRSF9 (Q07011) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data and structural context.
G70C (p.Gly70Cys) variant details
- p.Gly70Cys
- rs1399281402
- NCI-TCGA Cosmic COSV1010
- NCI-TCGA Cosmic COSV6634
- cosmic curated COSV66348
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.756
- REVEL 0.68
- CADD 35.00
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available