C65W (p.Cys65Trp) variant of TNFRSF9 (Q07011)
C65W (p.Cys65Trp) in TNFRSF9 (Q07011) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
C65W (p.Cys65Trp) variant details
- p.Cys65Trp
- ExAC rs766596112
- TOPMed rs766596112
- gnomAD rs766596112
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.643
- REVEL 0.75
- CADD 24.70
- PolyPhen-2 0.98
- SIFT 0.00
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 6.3e-06)
- Structural context available