S57R (p.Ser57Arg) variant of TNFRSF4 (P43489)
S57R (p.Ser57Arg) in TNFRSF4 (P43489) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
S57R (p.Ser57Arg) variant details
- p.Ser57Arg
- NCI-TCGA TCGA novel
- gnomAD rs1373497203
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.156
- REVEL 0.20
- CADD 5.14
- PolyPhen-2 0.01
- SIFT 0.18
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available