G11W (p.Gly11Trp) variant of TNFRSF4 (P43489)
G11W (p.Gly11Trp) in TNFRSF4 (P43489) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
G11W (p.Gly11Trp) variant details
- p.Gly11Trp
- ESP rs376504072
- ExAC rs376504072
- TOPMed rs376504072
- gnomAD rs376504072
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.211
- REVEL 0.21
- CADD 18.50
- PolyPhen-2 0.98
- SIFT 0.01
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available