W17C (p.Trp17Cys) variant of TNFRSF1B (P20333)
W17C (p.Trp17Cys) in TNFRSF1B (P20333) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, published literature, and structural context.
W17C (p.Trp17Cys) variant details
- p.Trp17Cys
- gnomAD 1-12167142-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.454
- REVEL 0.42
- MetaLR 0.78
- MetaSVM 0.06
- CADD 25.30
- PolyPhen-2 0.78
- SIFT 0.09
- Most common in the South Asian population (allele frequency 2e-05)
- Structural context available
- Literature evidence available