P34L (p.Pro34Leu) variant of TNFRSF1B (P20333)
P34L (p.Pro34Leu) in TNFRSF1B (P20333) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
P34L (p.Pro34Leu) variant details
- p.Pro34Leu
- cosmic curated COSV66164
- ExAC rs760020939
- TOPMed rs760020939
- gnomAD rs760020939
- Missense
- Variant Prioritization Score for Impact Estimate 0.177
- REVEL 0.12
- MetaLR 0.63
- MetaSVM -0.32
- CADD 7.41
- PolyPhen-2 0.03
- SIFT 0.18
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available