L10M (p.Leu10Met) variant of TNFRSF1B (P20333)
L10M (p.Leu10Met) in TNFRSF1B (P20333) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, published literature, and structural context.
L10M (p.Leu10Met) variant details
- p.Leu10Met
- gnomAD 1-12167119-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.533
- REVEL 0.43
- MetaLR 0.88
- MetaSVM 0.31
- CADD 24.80
- PolyPhen-2 1.00
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 1e-06)
- Structural context available
- Literature evidence available