H21Y (p.His21Tyr) variant of TNFRSF1B (P20333)
H21Y (p.His21Tyr) in TNFRSF1B (P20333) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
H21Y (p.His21Tyr) variant details
- p.His21Tyr
- gnomAD 1-12167152-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.316
- REVEL 0.29
- MetaLR 0.59
- MetaSVM -0.32
- CADD 6.60
- PolyPhen-2 0.02
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 1e-06)
- Structural context available
- Literature evidence available