A22T (p.Ala22Thr) variant of TNFRSF1B (P20333)
A22T (p.Ala22Thr) in TNFRSF1B (P20333) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, published literature, and structural context.
A22T (p.Ala22Thr) variant details
- p.Ala22Thr
- gnomAD 1-12167155-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.378
- REVEL 0.23
- MetaLR 0.52
- MetaSVM -0.31
- CADD 11.50
- PolyPhen-2 0.00
- SIFT 0.41
- Most common in the East Asian population (allele frequency 3.8e-05)
- Structural context available
- Literature evidence available