S25L (p.Ser25Leu) variant of TNFRSF1A (P19438)
S25L (p.Ser25Leu) in TNFRSF1A (P19438) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
S25L (p.Ser25Leu) variant details
- p.Ser25Leu
- NCI-TCGA Cosmic COSV5082
- cosmic curated COSV50827
- Ensembl rs1948089967
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.528
- REVEL 0.46
- CADD 15.00
- PolyPhen-2 0.00
- SIFT 0.36
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available