R133G (p.Arg133Gly) variant of TNFRSF1A (P19438)
R133G (p.Arg133Gly) in TNFRSF1A (P19438) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
R133G (p.Arg133Gly) variant details
- p.Arg133Gly
- ExAC rs771210186
- TOPMed rs771210186
- gnomAD rs771210186
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.553
- REVEL 0.57
- CADD 28.40
- PolyPhen-2 0.95
- SIFT 0.00
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available