P75Q (p.Pro75Gln) variant of TNFRSF1A (P19438)
P75Q (p.Pro75Gln) in TNFRSF1A (P19438) is a missense change. Clinical records from EBI and UniProt describe it as benign in the context of in FPF. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
P75Q (p.Pro75Gln) variant details
- p.Pro75Gln
- 1000Genomes rs4149637
- ESP rs4149637
- ExAC rs4149637
- TOPMed rs4149637
- Benign
- in FPF
- Missense
- Variant Prioritization Score for Impact Estimate 0.504
- REVEL 0.47
- CADD 22.30
- PolyPhen-2 0.60
- SIFT 0.04
- EBI: Benign (in FPF)
- UniProt: Benign (in FPF)
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available