H155Y (p.His155Tyr) variant of TNFRSF1A (P19438)
H155Y (p.His155Tyr) in TNFRSF1A (P19438) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as pathogenic in the context of Behcet disease. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes structural context.
H155Y (p.His155Tyr) variant details
- p.His155Tyr
- rs886039866
- ClinGen CA10590110
- ClinVar RCV000258049
- Ensembl rs886039866
- Pathogenic
- Behcet disease
- Missense
- Variant Prioritization Score for Impact Estimate 0.455
- AlphaMissense 0.09
- MetaLR 0.51
- MetaSVM -0.36
- PolyPhen-2 0.31
- SIFT 0.23
- EVE 0.32
- ClinVar: Pathogenic (Behcet disease)
- EBI: Pathogenic
- UniProt: Pathogenic
- Structural context available