E74K (p.Glu74Lys) variant of TNFRSF13B (O14836)
E74K (p.Glu74Lys) in TNFRSF13B (O14836) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data.
E74K (p.Glu74Lys) variant details
- p.Glu74Lys
- rs764542734
- cosmic curated COSV10506
- ExAC rs764542734
- TOPMed rs764542734
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.569
- REVEL 0.56
- CADD 24.00
- PolyPhen-2 0.46
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00012)