C34Y (p.Cys34Tyr) variant of TNFRSF13B (O14836)
C34Y (p.Cys34Tyr) in TNFRSF13B (O14836) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data.
C34Y (p.Cys34Tyr) variant details
- p.Cys34Tyr
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.748
- REVEL 0.74
- CADD 24.00
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:MXL population (allele frequency 0.0081)